Severely Suppressed Bone Turnover and Atypical Skeletal Fragility

Severely suppressed bone turnover: a potential complication of alendronate therapy.

Alendronate, an inhibitor of bone resorption, is widely used in osteoporosis treatment. However, concerns have been raised about potential oversuppression of bone turnover during long-term use. We report on nine patients who sustained spontaneous nonspinal fractures while on alendronate therapy, six of whom displayed either delayed or absent fracture healing for 3 months to 2 yr during therapy....

Trabecular bone mineralization of biopsies from fracture patients with severely suppressed bone turnover (SSBT)

INTRODUCTION: Bisphosphonates (BPs) are commonly prescribed drugs for the treatment of osteoporosis, a condition of increased fracture risk. BPs inhibit bone resorption and decrease bone turnover and bone loss. Longterm use of BPs may be associated with changes in the mechanical integrity of the bones of some patients. Odvina et al [1] were the first to report on a group of nine patients who su...

Skeletal fragility and bone quality.

Clusters and composites: Bone turnover and femoral neck fragility.

Bone Turnover Is Suppressed in Insulin Resistance, Independent of Adiposity.

Context The contribution of insulin resistance vs adiposity to bone mineral density (BMD), bone turnover, and fractures in humans remains unclear. Objective To evaluate BMD and bone turnover markers (BTMs) in lean (n = 18) and overweight/obese individuals with (n = 17) and without (n = 34, insulin-sensitive [Obsensitive, n=15] or insulin-resistant [Obresistant, n=19] by homeostasis model asse...